Carolyn M. Lutzko, PhD

Director, Cell Manipulation Laboratory and Translational Research and Development, Translational Core Laboratory
Division Director, Regenerative Medicine and Cellular Therapies, Hoxworth Blood Center
Professor, UC Department of Pediatrics

carolyn.lutzko@cchmc.org

About

BA: University of Guelph, S.Sc. Hon, Molecular Biology and Genetics Guelph, Ontario, Canada 1992.

PhD: University of Toronto, PhD Department of Laboratory Medicine Toronto, Ontario, Canada 1999.

Fellowship: Childrens Hospital Los Angeles Department of Pediatrics Division of Research Immunology/BMT Los Angeles, CA, 1999-2002.

Interests

Regulating human pluripotent stem cell; somatic cell reprogramming in iPSC; human embryonic stem cell physiology and differentiation; hESC; cystic fibrosis

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Selected

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium. Salomonis, N; Dexheimer, PJ; Omberg, L; Schroll, R; Bush, S; Huo, J; Schriml, L; Sui, SH; Keddache, M; Mayhew, C; Malik, P; Cancelas, JA; Aronow, BJ; Lutzko, C. Stem Cell Reports. 2016; 7:110-125.

Selected

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. Nayak, RC; Trump, LR; Aronow, BJ; Myers, K; Mehta, P; Kalfa, T; Wellendorf, AM; Valencia, CA; Paddison, PJ; Horwitz, MS; Grimes, HL; Lutzko, C; Cancelas, JA. The Journal of Clinical Investigation. 2015; 125:3103-3116.

G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates. Nayak, RC; Emberesh, S; Trump, LR; Wellendorf, AM; Singh, AK; Korkmaz, B; Horwitz, MS; Myers, KC; Kalfa, TA; Lutzko, CM; Cancelas, JA. The Journal of Clinical Investigation. 2025; 135:e177342.

Loss of ATG5 in Humans Causes Syndromic Congenital Dyserythropoietic Anemia with Impaired Mitophagy in Late Stages of Terminal Erythropoiesis. Ntoumaziou, A; Nguyen, D; Elgammal, Y; Husami, A; Zhang, W; Weaver, KD; Kasten, JL; Grier, DD; Zheng, Y; Lutzko, C; Risinger, M; Frayne, J; Seu, K; Kalfa, TA. Blood. 2024; 144:1084.

The Dominant Negative Acting VPS4AE228Q Mutation Causes Dyserythropoiesis in Human iPSC-Derived Erythroblast Cultures That Phenocopies Cimdag Syndrome-Associated Anemia. Gatterdam, C; Emberesh, S; Elgammal, Y; Lutzko, C; Blanc, L; Cancelas, J; Kalfa, TA; Seu, K. Blood. 2024; 144:2458.

Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant. Khoury, R; Grimley, MS; Nelson, AS; Leemhuis, T; Cancelas, JA; Cook, E; Wang, YZ; Heyenbruch, D; Bollard, CM; Keller, MD; Hanley, PJ; Lutzko, C; Pham, G; Davies, SM; Rubinstein, JD. American Journal of Transplantation. 2024; 24:1634-1643.

A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice. Arumugam, P; Carey, BC; Wikenheiser-Brokamp, KA; Krischer, J; Wessendarp, M; Shima, K; Chalk, C; Stock, J; Ma, Y; Black, D; Lowe-Daniels, D; Reeves, L; Kaiser, A; Trapnell, BC. Molecular Therapy-Methods & Clinical Development. 2024; 32:101213.

CMV SEROSTATUS IS MOST IMPORTANT TO SELECT DONORS OF MONONUCLEAR CELL PRODUCTS AIMED TO THE GENERATION OF ANTI-CMV VIRUS-SPECIFIC T CELL (VSTS) PRODUCTS. Ikegami, S; Amanda, D; Heyenbruch, D; Leemhuis, T; Lutzko, C; Alquist, CR; Cancelas, J. Cytotherapy (Informa). 2024; 26:e20-e21.

Erythrocyte Disorders Mimicking Congenital Dyserythropoietic Anemia Based on Bone Marrow Pathology Exposed By Genetic Evaluation. Ceolan, J; Seu, K; Ntoumaziou, A; Elgammal, Y; Emberesh, S; Bilston, L; Richards, D; Dickerson, KE; Chonat, S; Rydz, N; Lutzko, C; Husami, A; Zhang, W; Kalfa, TA. Blood. 2023; 142:2459.

Third-Party and Patient-Specific Donor-Derived Virus-Specific T Cells Demonstrate Similar Efficacy and Safety for Management of Viral Infections after Hematopoietic Stem Cell Transplantation in Children and Young Adults. Galletta, TJ; Lane, A; Lutzko, C; Leemhuis, T; Cancelas, JA; Khoury, R; Wang, YZ M; Hanley, PJ; Keller, MD; Bollard, CM; Davies, SM; Grimley, MS; Rubinstein, JD. Transplantation and Cellular Therapy. 2023; 29:305-310.

From the Blog

Infectious Diseases and Vaccines

Highlighting Heroes: Turnaround Enables COVID-19 Testing for Employees and Patients

Carolyn M. Lutzko, PhD4/2/2020