Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Impact of seizure onset zone and intracranial electroencephalography ictal characteristics on epilepsy surgery outcomes in tuberous sclerosis complex. Miecznikowski, KB; Leach, J; Rozhkov, L; Mangano, FT; Skoch, J; Krueger, DA; Horn, PS; Greiner, HM. Epilepsy Research. 2024; 205:107422.

Diagnostic Utility of Pre-Genomic Hepatitis B RNA in the Evaluation of HBV/HIV Coinfection. Sherman, KE; Rouster, SD; Meeds, H; Peters, MG; Blackard, JT; Horn, PS; Archampong, T; Kwara, A; Anderson, M; Stec, M; Cloherty, GA. Pathogens and Immunity. 2024; 9:43-57.

Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity. Pedapati, EV; Ethridge, LE; Liu, Y; Liu, R; Sweeney, JA; DeStefano, LA; Miyakoshi, M; Razak, K; Schmitt, LM; Moore, DR; Dominick, KC; Horn, PS; Binder, D; Erickson, CA. 2024.

Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results. Capal, JK; Ritter, DM; Franz, DN; Griffith, M; Currans, K; Kent, B; Martina Bebin, E; Northrup, H; Koenig, MK; Mizuno, T; Greiner, HM; Holland-Bouley, K; Horn, PS; Krueger, DA. 2024; 2:106-119.

Appendicular lean mass index changes in patients with Duchenne muscular dystrophy and Becker muscular dystrophy. Wong, BL; Summer, S; Horn, PS; Rutter, MM; Rybalsky, I; Tian, C; Shellenbarger, KC; Kalkwarf, HJ. Journal of Cachexia, Sarcopenia and Muscle. 2023; 14:2804-2812.

Reliability of resting-state electrophysiology in fragile X syndrome. Liu, R; Pedapati, EV; Schmitt, LM; Shaffer, RC; Smith, EG; Dominick, KC; DeStefano, LA; Westerkamp, G; Horn, P; Sweeney, JA; Erickson, CA. Biomarkers in Neuropsychiatry. 2023; 9.

Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder. Schmitt, LM; Smith, EG; Pedapati, EV; Horn, PS; Will, M; Lamy, M; Barber, L; Trebley, J; Meyer, K; Heiman, M; West, KH J; Hughes, P; Ahuja, S; Erickson, CA. Scientific Reports. 2023; 13:5192.

A sensitive and reproducible qRT-PCR assay detects physiological relevant trace levels of FMR1 mRNA in individuals with Fragile X syndrome. Straub, D; Schmitt, LM; Boggs, AE; Horn, PS; Dominick, KC; Gross, C; Erickson, CA. Scientific Reports. 2023; 13:3808.

MiR-324-5p inhibition after intrahippocampal kainic acid-induced status epilepticus does not prevent epileptogenesis in mice. McGann, AM; Westerkamp, GC; Chalasani, A; Danzer, CS K; Parkins, EV; Rajathi, V; Horn, PS; Pedapati, EV; Tiwari, D; Danzer, SC; Gross, C. Frontiers in Neurology. 2023; 14:1280606.

Characterization of Migraine in Children and Adolescents With Generalized Joint Hypermobility: A Case-Control Study. Ghosh, A; Horn, PS; Kabbouche Samaha, M; Kacperski, J; Lecates, SL; White, S; Powers, SW; Hershey, AD. Neurology: Clinical Practice. 2023; 13:e200188.

Our Response to the IV Fluid Shortage