Paul S. Horn, PhD

Biostatistician, Division of Neurology
Professor, UC Department of Pediatrics

paul.horn@cchmc.org

About

Biography

My area of research is statistical analysis and how to apply general statistical methodology to specific pediatric problems. I want to improve statistical analysis in pediatrics to provide more reliable evidence for decision making.

I am interested in providing answers to questions regarding the statistical methodology that applies to pediatric populations, such as appropriate reference ranges. One of my achievements is the development of quantile estimators that are relatively robust for smaller sample sizes.

I am a member of the International Committee for the Clinical and Laboratory Standards Institute. My career spans more 39 years, and I have worked at Cincinnati Children’s since 2013. My research has been published in various respected journals, including Interdisciplinary Neurosurgery, Advanced Techniques and Case Management, Neuroscience, Frontiers in Integrative Neuroscience, Muscle and Nerve, and Neurology.

Services and Specialties

Neurology

Interests

Robustness; nonparametrics; statistical computing; simulations; reference intervals.

Research Areas

Neurology

Publications

Language Mapping With rTMS in Healthy Pediatric Patients. Vedala, K; Kadis, DS; Vannest, J; Sino, S; Horn, PS; Maue, E; Williamson, B; Mangano, FT; Leach, JL; Greiner, HM. Journal of Clinical Neurophysiology. 2026; 43(1):68-78.

Responsive Neurostimulation of Thalamic and Nonthalamic Targets in Pediatric and Young Adult Patients With Intractable Epilepsy. Larrew, T; Greiner, HM; Arya, R; Tenney, JR; Aungaroon, G; Clark, DJ; Vedala, K; Drake, AW; Leach, JL; Horn, PS; Skoch, J; Mangano, FT. Neurosurgery. 2026; 98(1):204-210.

Limited Utility for Head Ultrasounds in the Evaluation of Tuberous Sclerosis Complex. Stultz, S; Krueger, DA; Franz, DN; Horn, PS; Ritter, DM. Pediatric Neurology. 2026; 174:86-90.

Localization and duration dependent effects of pediatric refractory epilepsy on language function. Ervin, B; Agarwal, Y; Buroker, J; Scholle, C; Rozhkov, L; Cummins, T; Byars, AW; Horn, PS; Skoch, J; Mangano, FT; Holland, KD; Tenney, JR; Greiner, HM; Arya, R. Epilepsy and Behavior. 2026; 174:110813.

Projecting US Population Eligibility for Minimally Invasive Surgical Evacuation of Intracerebral Hemorrhage. Wechsler, PM; Sucharew, H; Robinson, DJ; Stanton, RJ; Aziz, YN; Prestigiacomo, C; Demel, SL; Horn, P; Maloney, TC; Williamson, BJ; Flaherty, ML; Mistry, EA; Vagal, A; Khatri, P. Stroke. 2025; 56(12):3532-3537.

Extensive ischemic change on stroke presentation is uncommon: A population-based study. Aziz, YN; Vagal, A; Sucharew, H; Williamson, BJ; Khandwala, V; Wang, L; Cornelius, R; Gaskill-Shipley, MF; Tomsick, TA; Wang, DT; Stanton, RJ; Mistry, EA; Kissela, B; Khatri, P. Journal of Stroke and Cerebrovascular Diseases. 2025; 34(12):108488.

Elevated Levels of Active GSK3β in the Blood of Patients with Myotonic Dystrophy Type 1 Correlate with Muscle Weakness. Jennings, K; Tian, C; Brown, RL; Horn, PS; Schoser, B; Kushlaf, H; Timchenko, NA; Timchenko, L. International Journal of Molecular Sciences. 2025; 26(21).

Behavior-iEEG-Spectral-Power-Correlation: Defining Neural Substrates of Naturalistic Behavior. Ervin, B; Frink, C; Buroker, J; Horn, PS; Byars, AW; Scholle, C; Greiner, HM; Mangano, FT; Holland, KD; Hickok, G; Crone, NE; Arya, R. Annals of Neurology. 2025; 98(5):1096-1110.

Relationship Between Intellectual Disability and Behavioral Comorbidity in Children With Fragile X Syndrome. Kaufmann, WE; Horn, PS; Budimirovic, DB; Harris, HK; Lozano, R. Journal of Autism and Developmental Disorders. 2025.

Moral Distress in Pediatric Physician Trainees Caring for Patients With Neurologic Conditions. Didomenico, L; Horn, PS; Cortezzo, DE; Vawter-Lee, M; Venkatesan, C. Journal of Child Neurology. 2025; 8830738251376745.