Fukun Guo, PhD

Member, Division of Experimental Hematology & Cancer Biology
Professor, UC Department of Pediatrics

fukun.guo@cchmc.org

About

Biography

I joined Cincinnati Children’s Hospital Medical Center in 2002 after training as a molecular and cellular biologist. I have an extensive background and long-term interest in immunology. Currently, I investigate the role and mechanisms of Rho family GTPases in T lymphocyte development and function.

Since beginning my work, I helped discover the role of Rho GTPases in T lymphocyte metabolism, which is important for T lymphocyte-mediated autoimmunity and allergy. Also, I helped determine the role of Rho family GTPases in anti-tumor T cell immunity.

My research has consistently been supported by National Institutes of Health (NIH) awards. I am also a reviewer of NIH grants for others’ research projects.

Interests

Rho GTPases and T and B lymphocyte development and function

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Efficacy and advantage of immunotherapy for melanoma via intramuscular co-expression of plasmid-encoded PD-1 and CTLA-4 scFvs. Yang, Y; Huang, Q; Cheng, M; Deng, L; Liu, X; Zheng, X; Wei, J; Lei, Y; Li, X; Guo, F; Deng, Y; Zheng, Y; Bi, F; Wang, G; Liu, M. AMERICAN JOURNAL OF CANCER RESEARCH. 2024; 14:2626-2642.

Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. Zhu, M; Xiao, B; Xue, T; Qin, S; Ding, J; Wu, Y; Tang, Q; Huang, M; Zhao, N; Ye, Y; Guo, F; Jiang, Y; Zhang, L; Zhang, L. Brain: a journal of neurology. 2023; 146:4350-4365.

Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; Tian, W; Zheng, Y. Leukemia. 2023; 37:2073-2081.

Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Modur, V; Muhammad, B; Yang, JQ; Zheng, Y; Komurov, K; Guo, F. Cell Reports. 2023; 42:112364.

Cdc42 signaling regulated by dopamine D2 receptor correlatively links specific brain regions of hippocampus to cocaine addiction. Li, J; Wu, Y; Xue, T; He, J; Zhang, L; Liu, Y; Zhao, J; Chen, Z; Xie, M; Xiao, B; Liu, N; Guo, F; Zhang, L; Zhang, L. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease. 2023; 1869:166569.

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Kalim, KW; Yang, JQ; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; Jegga, AG; Zheng, Y; Guo, F. Journal for ImmunoTherapy of Cancer. 2022; 10.

Tumors bearing defective transcription elongation are immune hot but resistant to immune checkpoint inhibitors. Modur, V; Guo, F. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:119.11.

Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease. Ying, L; Zhao, J; Ye, Y; Liu, Y; Xiao, B; Xue, T; Zhu, H; Wu, Y; He, J; Qin, S; Jiang, Y; Guo, F; Zhang, L; Liu, N; Zhang, L. Aging Cell. 2022; 21:e13588.

Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery. Ao, Z; Cai, H; Wu, Z; Krzesniak, J; Tian, C; Lai, YY; Mackie, K; Guo, F. Analytical Chemistry. 2022; 94:1365-1372.

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Frontiers in Immunology. 2021; 12:726393.

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