Jocelyn M. Biagini, PhD

Associate Professor, UC Department of Pediatrics

jocelyn.biagini@cchmc.org

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Our long-term goals are to improve the health of children by conducting research that advances the field of asthma and allergic disease research by investigating the interplay of genetics with environmental exposures.

About

Biography

As a molecular epidemiologist, I am engaged in researching pediatric allergic diseases. My special interests include asthma and food allergy, allergic disease progression, and the genomic and environmental contributions to allergic diseases in children. I was drawn to these research areas after growing up with seasonal allergies and asthma, and by my love of pediatric research.

In the Biagini Lab, our long-term goals are to improve the health of children by conducting research that advances the field of asthma and allergic disease research by investigating the interplay of genetics with environmental exposures. We are also studying the mechanisms underlying the progression of disease from food allergy to asthma and the biology underlying severe asthma in children.

We recently published the Pediatric Asthma Risk Score (PARS), which is the first continuous risk score for asthma in children. It relies on factors that are routinely collected in the assessment of a child being evaluated for allergy, asthma or both. It is superior to the traditional Asthma Predictive Index (API) with an 11% increase in sensitivity due to improved prediction in children with mild-to-moderate asthma risk.

I am an elected member to the American Academy of Asthma, Allergy and Immunology and a member of the editorial board for the Journal of Asthma. I began my career in 2001 and joined the Cincinnati Children’s team in 2008.

Research Areas

Asthma

Publications

Selected

A Pediatric Asthma Risk Score to better predict asthma development in young children. Biagini Myers, JM; Schauberger, E; He, H; Martin, LJ; Kroner, J; Hill, GM; Ryan, PH; LeMasters, GK; Bernstein, DI; Lockey, JE; Arshad, SH; Kurukulaaratchy, R; Hershey, GK K. Journal of Allergy and Clinical Immunology. 2019; 143:1803-1810.e2.

Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis. DeVore, SB; Stevens, ML; He, H; Biagini, JM; Kroner, JW; Martin, LJ; Khurana Hershey, GK. Journal of Allergy and Clinical Immunology. 2022; 149:708-717.

TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. Murrison, LB; Ren, X; Preusse, K; He, H; Kroner, J; Chen, X; Jenkins, S; Johansson, E; Biagini, JM; Weirauch, MT; Kopan, R; Martin, LJ; Khurana Hershey, GK. Journal of Allergy and Clinical Immunology. 2022; 149:79-88.

Pediatric asthma incidence rates in the United States from 1980 to 2017. Johnson, CC; Havstad, SL; Ownby, DR; Joseph, CL M; Sitarik, AR; Biagini Myers, J; Gebretsadik, T; Hartert, TV; Khurana Hershey, GK; Jackson, DJ; Miller, RL; Seroogy, CM; Wright, AL; Gern, JE. Journal of Allergy and Clinical Immunology. 2021; 148:1270-1280.

Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity. Johansson, E; Martin, LJ; He, H; Chen, X; Weirauch, MT; Kroner, JW; Khurana Hershey, GK; Biagini, JM. Clinical and Experimental Allergy. 2021; 51:801-810.

Nasal DNA methylation differentiates severe from non-severe asthma in African-American children. Zhu, T; Zhang, X; Chen, X; Brown, AP; Weirauch, MT; Guilbert, TW; Khurana Hershey, GK; Biagini, JM; Ji, H. Allergy: European Journal of Allergy and Clinical Immunology. 2021; 76:1836-1845.

Sensitization to peanut, egg or pets is associated with skin barrier dysfunction in children with atopic dermatitis. Sherenian, MG; Kothari, A; Biagini, JM; Kroner, JW; Baatyrbek kyzy, A; Johannson, E; Atluri, G; He, H; Martin, LJ; Khurana Hershey, GK. Clinical and Experimental Allergy. 2021; 51:666-673.

NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure. Brooks, CC; Martin, LJ; Pilipenko, V; He, H; LeMasters, GK; Lockey, JE; Bernstein, DI; Ryan, PH; Hershey, GK K; Myers, JM B. Journal of Asthma (Informa). 2021; 58:284-292.

A distributed geospatial approach to describe community characteristics for multisite studies. Ryan, PH; Brokamp, C; Blossom, J; Lothrop, N; Miller, RL; Beamer, PI; Visness, CM; Zanobetti, A; Andrews, H; Bacharier, LB; Mikus, L; Bach, J; Wood, R; Matsui, E. Journal of Clinical and Translational Science. 2021; 5:e86.

Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort. Gonzalez, T; Stevens, ML; Kyzy, AB; Alarcon, R; He, H; Kroner, JW; Spagna, D; Grashel, B; Sidler, E; Martin, LJ; Myers, JM B; Hershey, GK K; Herr, AB. Allergy: European Journal of Allergy and Clinical Immunology. 2021; 76:302-313.