About
MD: Nagoya University, Nagoya, Japan, 2003.
PhD: Tokyo University, Tokyo, Japan, 2008.
Residency: Pediatrics, Columbia University, New York, NY.
Certification: Pediatrics, 2010.
Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Northwestern University, Chicago, IL.
Certification: Pediatric Gastroenterology, Hepatology and Nutrition, 2013.
Fellowship: Advanced/Transplant Hepatology, University of Cincinnati, Cincinnati, OH.
Certification: Advanced/Transplant Hepatology.
Interests
Pediatric hepatology; pediatric transplant hepatology
Services and Specialties
Gastroenterology GI, Liver Transplant, Autoimmune Liver Disease, Liver Care, Liver Tumor
Interests
Pediatric hepatology; genetic and molecular mechanism of liver development and pathophysiology
Research Areas
Gastroenterology Hepatology and Nutrition
Additional Languages
Japanese
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
The Outcome of Patients With Cystic Biliary Atresia With Intact Proximal Hepatic Ducts Following Hepatic-Cyst-Jejunostomy. Journal of Pediatric Gastroenterology and Nutrition. 2022; 75:131-137.
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. JHEP Reports. 2022; 4:100446.
Biliary Atresia and Other Disorders of the Extrahepatic Bile Ducts. Liver Disease in Children. : Cambridge University Press (CUP); Cambridge University Press (CUP); 2021.
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16:309-323.
Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes. Nature Reviews: Gastroenterology and Hepatology. 2015; 12:342-352.
Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV. Molecular Genetics and Metabolism Reports. 2024; 39:101069.
Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles. Hepatology Communications. 2024; 8.
Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. Hepatology Communications. 2023; 7.
Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses. The Journal of Pediatrics. 2023; 259:113439.
Customized Postoperative Therapy Improves Bile Drainage in Biliary Atresia: A Single Center Preliminary Report. Journal of Pediatric Surgery. 2023; 58:1483-1488.
From the Blog
Cincinnati Children’s Launches Research Center for Rare Liver Diseases
Akihiro Asai, MD, PhD, William F. Balistreri, MD ...12/6/2021
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