Yin Research Lab
The long-term goal of the Yin Lab, led by Chunyue Yin, PhD, is to uncover the mechanisms driving liver development, homeostasis, and disease etiology. We combine genetic tools and in vitro and in vivo experimental models to explore fundamental questions in liver biology.
Our current focus is on inherited chronic intrahepatic cholestasis, with two primary research goals:
- Understanding how known gene mutations cause cholestasis, using zebrafish and mouse models.
- Discovering new disease-causing genes to improve diagnosis and enable personalized treatment strategies.
As part of the Center for Undiagnosed and Rare Liver Disease, we work closely with clinicians, geneticists, and pathologists to identify novel genetic variants causing inherited chronic cholestasis. Through in vitro cell line models and pre-clinical animal models, we validate these variants, investigate disease mechanisms, and develop targeted therapeutic approaches.
