Research for Allergic and Immunological Diseases

The Division of Allergy and Immunology at Cincinnati Children’s conducts leading research focused on elucidating the causes, mechanisms and most effective treatment of allergic and immunological diseases.

Mission

To improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research.

Bench to Bedside

Our research spans fundamental studies, translational investigations, genetic and genomic analyses, computational science, and clinical trials to enhance our understanding of immunity with a focus on mast cells, eosinophils, macrophages, lymphocytes, epithelium and stem cells.

Innovation

Laboratories are led by nationally recognized researchers and employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis, including novel models of immunological diseases, developed and / or fine-tuned by divisional researchers to provide unprecedented systems to investigate key inflammatory steps involved in allergic and immunological disease.

Fundamental Studies

We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.

Translational Investigation

We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disorders, inflammatory bowel disease and food allergy and liver disease) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations), hypereosinophilic syndrome (IL-5 and activated tyrosine kinases), asthma (T helper cytokines), food allergy (mast cells and effector memory T cells and T regulatory cells), liver disease such as metabolic dysfunction-associated steatohepatitis (MASH) are focus areas.

Clinical Trials

We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome), and food allergy. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized. Learn more about our clinical trials.